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This synthetic approach is relevant when aiming to conjugate two entities to an oligonucleotide as exemplified recently in the work of Aartsma-Rus and coworkers: conjugation of a homing peptide and a cell-penetrating peptide allows for increased targeted tissue delivery of a morpholino oligomer as compared to the conjugation of a single peptide 34

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In conclusion, these results indicate that mTOR signaling is finely regulated in different immune cells in the TME, and more clear preclinical studies are needed to confirm its role in antitumor immunity